Abstract
ANALYSIS OF BORASSUS AETHIOPUM SHOOT STARCH AS A BINDER IN A TABLET FORMULATION

A. Adamu, *J. Muazu and S. J. Madu

ABSTRACT

Binders are incorporated into granules to impart cohesiveness and also to ensure that a compressed tablet remains intact after compression. The binding properties of starch extracted from Borassus aethiopum shoot (Muruchi) was extracted and compared with maize starch BP. The properties considered included bulk density, tapped density, moisture content, Hausner’s ratio, Carr’s index, angle of repose of the sample starch powders and paracetamol granules produced. The tablets produced were also analyzed for quality. The outcome showed that Muruchi starch employed as mucilage (Binder) at 2.5, 5, 7.5 and 10 % concentrations respectively produced tablets comparable in friability, crushing strength, disintegration and dissolution time to tablets produced with maize starch BP binder. Therefore, it can be established that Borassus aethiopum shoot starch can be employed as an alternative binder to maize starch BP in the formulation of paracetamol tablets.

Keywords: Borassus aethiopum shoot, Starch, Tablet binder and Tablet formulation.


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